DuraGen Plus® Dural Regeneration Matrix (US)

For US Residents

The next generation onlay collagen matrix for cranial and spinal duraplasty.

DuraGen Plus Dural Regeneration Matrix is the next generation dural substitute from Integra. Building on the success of DuraGen® Dural Graft Matrix, the DuraGen Plus matrix has a more consistent collagen structure for superior handling.

DuraGen Plus meets the requirements of an onlay and delivers superior results

Requirements
 Function
Ultra Pure Collagen™
 No reported foreign body reaction; Fibrin Clot formation within the matrix creates a rapid mechanical barrier against CSF leakage.
Excellent Conformability
 Ensures graft approximation at the dural margin
Optimized Resorption
 Matrix resorbs at the same rate as new tissue forms
Engineered Porosity
 Facilitates tissue integration, no reported encapsulation

The leading collagen matrix for primary dural repair

  • Sutureless onlay graft for the repair of dural defects 1,2
  • Fully resorbed following complete dural closure2
  • Not encapsulated following neuro-surgical implantation2,3
  • Easily conforms to complex surfaces
  • Available in sizes up to 5"x7"

Improved Handling

  • Handles and conforms similar to soft tissue3
  • Improved uniformity and consistency of pore structure3
  • Increased tensile strength when hydrated3
  • Either side of matrix can now be used against brain or spinal cord
  • Soft, pliable graft molds instantly to neural tissue.1
  • Suturing not required, but tensionless stay sutures may be used if desired.1
  • Easily cut to fit dural defects of any shape or size.1

DuraGen Plus, safe and effective in over 475,000 patients

  • Minimal adhesion formation only following significant disruption of pia-arachnoid.2,3
  • Effective protection against cerebrospinal fluid (CSF) leakage with sutureless closure.2,3
  • No Foreign body reactions or immune rejection reported.
  • Infection rate comparable to other methods of dural closure.**2
  • Immunologically well tolerated-no foreign body reactions reported in clinical trials. 2,3

Integra's Dural Regeneration Matrix - 30 years of science, innovation, and application

  • Integra’s Ultra Pure Collagen technology is the basis of products used by neuro, orthopedic, plastic & reconstructive, and oral surgeons
  • Integra’s Ultra Pure Collagen has been used in over 10 million procedures
  • Integra’s Ultra Pure Collagen is used to manufacture products for some of the world’s largest medical device companies
  • Integra offers a complete set of neurosurgical solutions for the repair of dura mater



Part Numbers: DP1011, DP1013, DP1022, DP1033, DP1045, DP1057, DP5011, DP5013, DP5013, DP5022, DP5033.
*The collagen used to manufacture DuraGen is currently used in the manufacture of a dermal regeneration template, absorbable hemostatic sponges and absorbable wound dressings.

**Patients in whom the dura was left open or sutured.

References
1. DuraGen® Instructions for Use, Integra LifeSciences Corporation;1999
2. Narotam PK, van Dellen JR, Bhoola KD. A clinicopathological study of collagen sponge as a dural graft in neurosurgery. J Neurosurg. 1995; 82:406-412.
3. Data on file, Integra LifeSciences Corporation.


For more information, please contact Integra Corporate Customer Service at 609-275-0500 or 800-654-2873.